Relationship-based practice revisited [editorial]

Editorial to Special Issue. This editorial introduces a special issue of the Journal of Social Work Practice called 'Relationship-based Practice Revisited'

Simplified SIMPs and the LHC

The existence of Dark Matter (DM) in the form of Strongly Interacting Massive Particles (SIMPs) may be motivated by astrophysical observations that challenge the classical Cold DM scenario. Other observations greatly constrain, but do not completely exclude, the SIMP alternative. The signature of SIMPs at the LHC may consist of neutral, hadron-like, trackless jets produced in pairs. We show that the absence of charged content can provide a very efficient tool to suppress dijet backgrounds at the LHC, thus enhancing the sensitivity to a potential SIMP signal. We illustrate this using a simplified SIMP model and present a detailed feasibility study based on simulations, including a dedicated detector response parametrization. We evaluate the expected sensitivity to various signal scenarios and tentatively consider the exclusion limits on the SIMP elastic cross section with nucleons.Comment: 18 pages, 7 figure

Metal Cooling in Simulations of Cosmic Structure Formation

The addition of metals to any gas can significantly alter its evolution by increasing the rate of radiative cooling. In star-forming environments, enhanced cooling can potentially lead to fragmentation and the formation of low-mass stars, where metal-free gas-clouds have been shown not to fragment. Adding metal cooling to numerical simulations has traditionally required a choice between speed and accuracy. We introduce a method that uses the sophisticated chemical network of the photoionization software, Cloudy, to include radiative cooling from a complete set of metals up to atomic number 30 (Zn) that can be used with large-scale three-dimensional hydrodynamic simulations. Our method is valid over an extremely large temperature range (10 K < T < 10^8 K), up to hydrogen number densities of 10^12 cm^-3. At this density, a sphere of 1 Msun has a radius of roughly 40 AU. We implement our method in the adaptive mesh refinement (AMR) hydrodynamic/N-body code, Enzo. Using cooling rates generated with this method, we study the physical conditions that led to the transition from Population III to Population II star formation. While C, O, Fe, and Si have been previously shown to make the strongest contribution to the cooling in low-metallicity gas, we find that up to 40% of the metal cooling comes from fine-structure emission by S, when solar abundance patterns are present. At metallicities, Z > 10^-4 Zsun, regions of density and temperature exist where gas is both thermally unstable and has a cooling time less than its dynamical time. We identify these doubly unstable regions as the most inducive to fragmentation. At high redshifts, the CMB inhibits efficient cooling at low temperatures and, thus, reduces the size of the doubly unstable regions, making fragmentation more difficult.Comment: 19 pages, 12 figures, significant revision, including new figure

In vivo nuclear magnetic resonance imaging

A number of physiological changes have been demonstrated in bone, muscle and blood after exposure of humans and animals to microgravity. Determining mechanisms and the development of effective countermeasures for long duration space missions is an important NASA goal. The advent of tomographic nuclear magnetic resonance imaging (NMR or MRI) gives NASA a way to greatly extend early studies of this phenomena in ways not previously possible; NMR is also noninvasive and safe. NMR provides both superb anatomical images for volume assessments of individual organs and quantification of chemical/physical changes induced in the examined tissues. The feasibility of NMR as a tool for human physiological research as it is affected by microgravity is demonstrated. The animal studies employed the rear limb suspended rat as a model of mucle atrophy that results from microgravity. And bedrest of normal male subjects was used to simulate the effects of microgravity on bone and muscle

Numerical Simulations of High Redshift Star Formation in Dwarf Galaxies

We present first results from three-dimensional hydrodynamic simulations of the high redshift formation of dwarf galaxies. The simulations use an Eulerian adaptive mesh refinement technique to follow the non-equilibrium chemistry of hydrogen and helium with cosmological initial conditions drawn from a popular Lambda-dominated CDM model. We include the effects of reionization using a uniform radiation field, a phenomenological description of the effect of star formation and, in a separate simulation, the effects of stellar feedback. The results highlight the effects of stellar feedback and photoionization on the baryon content and star formation of galaxies with virial temperatures of approximately 10^4K. Dwarf sized dark matter halos that assemble prior to reionization are able to form stars. Most halos of similar mass that assemble after reionization do not form stars by redshift of three. Dwarf galaxies that form stars show large variations in their gas content because of stellar feedback and photoionization effects. Baryon-to-dark matter mass ratios are found to lie below the cosmic mean as a result of stellar feedback. The supposed substructure problem of CDM is critically assessed on the basis of these results. The star formation histories modulated by radiative and stellar feedbacks are discussed. In addition, metallicities of individual objects are shown to be naturally correlated with their mass-to-light ratios as is also evident in the properties of local dwarf galaxies.Comment: 27 pages, 8 figures, accepted for publication in Ap

Exposure of Vascular Smooth Muscle Cells for Analysis with the Scanning Electron Microscope

There has been interest in using the scanning electron microscope (SEM) to study the structure of tissues obscured by other cellular or non-cellular elements almost since the SEM was first used to examine biological tissues. Such interest includes the vessel wall and, in particular, the vascular smooth muscle cells. This paper presents a review of the three basic methodologies that have been employed to allow examination of the vascular smooth muscle, 1) blunt dissection, 2) digestion and 3) microdissection. Discussion of other perivascular elements was not a focus of this review. Also presented is the application of these different methodologies to different pathophysiologic conditions